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Thanks to you, CCS is the largest national charitable funder of research into all types of cancer. Because of your generous contributions, research has led to new and more effective treatments for childhood cancers and an increase in the number of children who survive into adulthood.
Brain cancer is the leading cause of cancer death in Canadian children. But, thanks to a new CCS-funded study you helped make possible, new light has been shed on its origins a promising step toward better treatments.
Until now, our understanding and treatment of childhood brain cancer has been hindered by a lack of knowledge about “how, where and when” these tumours arise.
With your generous support, CCS-funded researcher Dr Claudia Kleinman and her team set out to address these critical gaps.
The team profiled more than 65,000 individual cells to create an atlas of two major areas of the brain where tumours commonly develop. They then used this atlas to map out three types of childhood brain tumours and trace their origins back to specific cells.
In a groundbreaking discovery, Dr Kleinman and her team found that these cells eventually became cancerous because their development stopped prematurely during fetal brain development.
These findings can now be used to help researchers develop better models to study childhood brain tumours, and to develop and test new treatments.
“I would like to thank you from the bottom of my heart,” says Dr Kleiman. “We couldn’t do what we do if it weren’t for supporters like you.”